Ketamine IV Infusions: Everything You Need to Know

Updated
June 29, 2023
Edited by Ben Smith
Last Updated:
May 2, 2024
Cheerful woman wearing yellow sunglasses, connected to a colorful IV drip, symbolizing joy and innovative treatments in mental health, surrounded by vibrant flowers.

Ketamine is a powerful drug that has been used for decades as an anesthetic, but more recently, it has been studied and used to treat mental health conditions like depression and anxiety. But how can ketamine be administered? And what are the benefits of ketamine infusions versus other methods?

How Can Ketamine Be Administered?

Ketamine can be administered through different methods, including intravenous (IV) infusion, intramuscular injection, nasal spray, and oral tablets. IV infusion is the most common form of administration for ketamine therapy because it allows for a more consistent delivery of the drug into the bloodstream. Despite this, oral tablets and home use have recently been growing in popularity, especially during the covid pandemic. 

How Do Ketamine IV Infusions Work?

The process starts with a patient receiving an IV line in their arm or hand. The ketamine is then administered directly into the bloodstream at a controlled rate over a period of time. This allows for steady absorption of the drug into the body, which can help increase its effectiveness. During treatment sessions, patients may experience feelings of relaxation or sedation due to the effects of the drug on their brain chemistry.

Benefits of Ketamine Infusions versus Other Methods

When administered through intravenous infusions, ketamine has demonstrated several benefits compared to other methods of administration:

  1. Ketamine infusions offer precise dosage control, ensuring a consistent and tailored treatment approach for each individual. This allows healthcare professionals to carefully adjust the infusion rate to achieve the desired therapeutic effect.
  2. Ketamine infusions bypass the first-pass metabolism, enabling a more rapid onset of action and avoiding potential drug degradation.
  3. The intravenous route ensures a higher bioavailability, maximizing the therapeutic potential of ketamine.
  4. Ketamine infusions can provide a longer duration of action, allowing for sustained relief and extended therapeutic effects.

Overall, ketamine infusions offer a reliable and effective method of administration that holds promise in various therapeutic applications.

What is the Effectiveness of Ketamine Infusions?

Ketamine infusions have shown remarkable effectiveness in various medical and psychiatric conditions. Studies have consistently demonstrated that ketamine infusions can provide rapid and robust relief from treatment-resistant depression, often within hours or days, compared to conventional antidepressant medications that can take weeks to show an effect [1]. Ketamine infusions have also shown promise in addressing chronic pain, such as neuropathic pain and complex regional pain syndrome, where other treatments have been unsuccessful [2].

Furthermore, ketamine infusions have been effective in managing acute suicidal ideation and have been used in emergency settings to stabilize individuals in psychiatric crises rapidly [3]. The effectiveness of ketamine infusions extends beyond mental health and pain management, with emerging research suggesting its potential in treating post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and substance use disorders.  

How do I get started with Ketamine Infusions?

If you're interested in exploring ketamine infusion therapy to treat your mental health condition, you should speak with your doctor about getting started. Your doctor will likely recommend an assessment by a qualified provider specializing in this type of treatment before beginning any therapy. From there, they will discuss the treatment's potential risks and benefits before deciding if it's right for you. 

Overall, ketamine infusion therapy treats mental health conditions such as depression and anxiety disorders when traditional medications fail to produce desired results. If you think this treatment might be right for you, talk to your doctor and look at our therapist directory to learn more. 

At Psychly, we are committed to upholding the highest standards in our content creation process. We strive to ensure that all statements presented in our articles are supported by reliable, high-quality sources, such as peer-reviewed studies and reputable academic journals.

- The Psychly Team

  1. Yavi, M., Lee, H., Henter, I. D., Park, L. T., & Zarate, C. A., Jr (2022). Ketamine treatment for depression: a review. Discover mental health2(1), 9. https://doi.org/10.1007/s44192-022-00012-3
  2. Chitneni, A., Patil, A., Dalal, S., Ghorayeb, J. H., Pham, Y. N., & Grigoropoulos, G. (2021). Use of Ketamine Infusions for Treatment of Complex Regional Pain Syndrome: A Systematic Review. Cureus13(10), e18910. https://doi.org/10.7759/cureus.18910
  3. Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., Sos, P., Wang, G., Zarate, C. A., Jr, & Sanacora, G. (2018). The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. The American journal of psychiatry175(2), 150–158. https://doi.org/10.1176/appi.ajp.2017.17040472

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