History of Ketamine for PTSD

While ketamine was discovered in the 1960s and primarily used as an anesthetic, its application for post-traumatic stress disorder (PTSD) came into view much later. The use of ketamine for psychiatric conditions such as depression began to gain traction in the 1990s and early 2000s.

In the early 2000s, pioneering work was carried out to explore the role of ketamine in alleviating the symptoms of PTSD, particularly among veterans who were refractory to traditional pharmacological therapies. Subsequent studies have supported the notion that ketamine, especially when employed in conjunction with psychotherapies such as cognitive behavioral therapy (CBT), may be beneficial for those suffering from PTSD.

Ketamine for PTSD

Ketamine works by blocking certain receptors in the brain, which improves mood. It is most commonly used as an intravenous infusion or intramuscular injection in treatment sessions that last between 30 minutes and two hours. Sessions can be repeated up to three times per week, depending on how well the patient responds to treatment. 

Benefits of Ketamine for PTSD versus Other Treatments

The main benefit of ketamine therapy for PTSD compared to other treatments is its rapid onset of action. Unlike traditional antidepressants, which can take weeks or months before they take effect, ketamine infusions can relieve symptoms within hours or days after administration. 

Moreover, emerging research suggests that ketamine might have a role in reducing suicidal ideation, which is particularly relevant given that PTSD can be associated with an increased risk of suicidal thoughts and behaviors.

Effectiveness of Ketamine for PTSD

Recent studies have been increasingly supportive of the efficacy of ketamine infusions in mitigating PTSD symptoms. A notable point is that ketamine tends to be more effective when used as part of a comprehensive treatment plan that includes psychotherapy, such as CBT. However, it’s essential to recognize that responses to ketamine treatment can vary, and more research is needed to establish long-term safety and efficacy.

For example, One study aims to investigate the effectiveness of combining a single infusion of ketamine with 7 days of trauma-focused psychotherapy in relieving symptoms of post-traumatic stress disorder (PTSD). By integrating these two approaches, the study aims to expedite the therapeutic process, potentially yielding a noteworthy reduction in symptoms that would typically require several months to achieve with other treatment options.^[1]. 

Who should avoid using Ketamine for PTSD? 

Although generally considered safe and effective, some people should avoid using ketamine therapy to treat their mental health condition. These include those who are pregnant; those taking certain medications; and those suffering from substance abuse disorders, among others. Therefore, it is important to consult your doctor before considering any form of treatment with ketamine infusion therapy if you fall into any of these categories. 

How do you get started with Ketamine for PTSD? 

If you think you can benefit from receiving treatment with ketamine infusion therapy, the first step is to speak to your doctor about it. They will assess whether this kind of treatment would suit you based on your medical history and current condition before referring you to a specialist clinic where they administer this type of treatment. Once referred on, it’s important to attend all your appointments and follow the instructions given by your doctor closely so that you receive the best possible outcome from your treatment plan.  

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