What is The History of Ketamine for Anxiety? 

Ketamine has been used off-label to treat anxiety since the turn of the century when it was first discovered to have similar effects to antidepressants. It was initially used as an anesthetic in medical settings, but its use as a treatment for mental health conditions such as anxiety and depression began to gain traction in the 1990s. Since then, ketamine has been studied extensively and found to be an effective treatment for many people with treatment-resistant depression and anxiety disorders.  

How does Ketamine Treat Anxiety?

Ketamine works by blocking NMDA receptors in the brain, which regulate mood and emotions ^[1]. When these receptors are blocked, it can reduce feelings of fear, worry, and stress associated with anxiety. Additionally, there is evidence that ketamine can help restore disrupted brain connectivity and improve neuroplasticity in people with mental health issues such as depression and anxiety ^[2]. This helps improve communication between different parts of the brain and can lead to better overall functioning and improved mental health.

Benefits of Ketamine Versus Other Treatments for Anxiety 

Ketamine offers distinct advantages over other anxiety treatments. Firstly, its onset of action is significantly faster than traditional medications like SSRIs or SNRIs. Many individuals experience relief from their anxiety symptoms within hours or days following a ketamine infusion therapy session. 

Moreover, ketamine has been shown to have a lower likelihood of causing side effects compared to conventional medications. Unlike other drugs that impact the entire body, ketamine selectively targets the specific brain regions responsible for mood and emotions. 

Lastly, ketamine infusions are typically administered by trained medical professionals in a clinical setting. This ensures that patients receive individualized care from experienced practitioners who possess the necessary expertise to safely and effectively administer the drug.

How Effective is Ketamine for Treating Anxiety?

The effectiveness of ketamine for treating anxiety varies from person to person depending on individual circumstances, such as the severity of symptoms and history of response to other treatments. However, research suggests that ketamine positively reduces anxiety symptoms in many people who have tried other treatments without success. A recent study also found that 70 percent of patients with treatment-resistant depression who were prescribed an oral antidepressant and received intranasal esketamine experienced improvements. In comparison, the group that did not receive the medication (known as the placebo group) had a slightly lower rate of improvement, with just over half of the patients showing positive changes ^[3].

Who should avoid using Ketamine for Anxiety?

Ketamine should not be used by anyone with a history of substance abuse or addiction due to its potentially addictive properties. Additionally, pregnant women should avoid using ketamine due to possible risks associated with fetal development. Finally, people with certain medical conditions, such as kidney disease, should consult their doctor before considering ketamine therapy. 

How do I get started with Ketamine Therapy for Anxiety?

If you’re interested in trying ketamine therapy for your anxiety symptoms, you’ll need to find a qualified practitioner who specializes in administering this type of therapy. You should also discuss any existing medical conditions or concerns with your practitioner so they can decide if this type of treatment is right for you. 

Once you have chosen a provider, they will create an individualized treatment plan that includes how often you need sessions and what dosage will work best for your particular needs.

‍